Understanding and Applying Read-Across for Human Health Risk Assessment

CalEPA Office of Environmental Health Hazard Assessment

WORKSHOP & WEBCAST

May 2, 2019

Webcast link:  https://video.calepa.ca.gov/

9:00     Welcome & Introductory Remarks

            Lauren Zeise, Director, Office of Environmental Health Hazard Assessment

SESSION I

SINGLE CHEMICAL READ-ACROSS APPROACHES IN PREDICTING HAZARD, POTENCY, AND RISK: WHERE ARE WE NOW?

Moderator: Ivan Rusyn, Texas A&M University

9:10     Read-Across in US EPA Provisional Peer-Reviewed Toxicity Values Assessments

            Jason Lambert, US Environmental Protection Agency (US EPA)

9:35     NTP Read-Across in the Report on Carcinogens: Haloacetic Acids

            Gloria Jahnke, National Toxicology Program (NTP)

10:00   Understanding Chemical and Mechanistic Classes: IARC Approach

            Vince Cogliano, US EPA

10:15   Panel Discussion

10:40   Break

SESSION II

READ-ACROSS PRINCIPLES IN TESTING AND ASSESSING PFAS CHEMICALS

 

Moderator: Weihsueh Chiu, Texas A&M University

11:00   PFAS Chemicals in California: The Current Need for Characterization

            Julie Henderson, Deputy Secretary for Heath and Public Policy, CalEPA

11:10   PFAS Prioritization for Targeted Testing

            Grace Patlewicz, US EPA

11:50   NTP Approach to Testing of PFAS Chemicals

            Mike DeVito, NTP

12:30   Break for Lunch

1:30     Approaches to Hazard and Dose Response Assessment

            Jason Lambert, US EPA

2:10     Panel and Audience Discussion

            Panelists:

            Session II & III Speakers

            Michele La Merrill, University of California, Davis

            Martyn Smith, University of California, Berkeley

            Tracey Woodruff, University of California, San Francisco

3:00     Break

SESSION III

USE OF COMPUTATIONAL METHODS IN READ-ACROSS

            Moderator: Melanie Marty, OEHHA

3:15     CTV & Integrating it into Read-Across

            Jessica Wignall, ICF

3:40     Use of GenRA to Assist in Read-Across

            Grace Patlewicz, US EPA National Center for Computational Toxicology

4:10     Navigating ChemMaps

            Nicole Kleinstreuer, National Institute for Environmental Health Sciences

4:40     Discussion

4:55     Closing Remarks